Any film from sibling directors Jean-Pierre and Luc Dardenne is cause for celebration. The filmmakers, known for their intimate stories that carry a big emotional impact, have carved out their own, highly satisfying niche in the arthouse world, and fans will soon have another reason get excited. Their latest film, “The Unknown Girl,” is headed to U.S. cinemas and today we have the exclusive trailer.

Starring Adele Haenel, Jeremie Renier, Olivier Bonnaud, and Louka Minnella, the story follows a young doctor who embarks on a journey to learn the identity of a woman she turned away, and who later wound up dead. Here’s the official synopsis:

The new film from acclaimed directors the Dardenne brothers (Two Days, One Night) is a searing saga of guilt and redemption. One evening after work hours, Jenny (Adèle Haenel), a young doctor, allows the door buzzer at the small clinic where she works to go unanswered. It’s only later that she learns that the person ringing was an unidentified African woman found dead shortly after by the side of a road. Consumed by the thought that she is to blame, Jenny embarks on an obsessive crusade to discover who the anonymous woman was and to see to it that she is not forgotten. Shot through with low-key suspense and the heart-stopping realism that has become the directors’ trademark, The Unknown Girl is both a gripping mystery and a profoundly human moral tale.

“The Unknown Girl” opens on September 8th.